Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine.However, this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness.In this work, we proposed a multiple reaction monitoring (MRM)-based fingerprinting meth
Switch-like responses arising from bistability have been linked to cell signaling processes and memory.Revealing the shape and properties of the set of parameters that lead to bistability is necessary to understand the underlying biological mechanisms, but is a complex mathematical problem.We present an efficient approach to address a basic topolog
Summary: Iron is essential for DNA synthesis, respiration, energy metabolism, and key metabolic reactions intrinsic to life because of its capability to accept and release electrons easily and its indispensability for most of the creatures on the earth including bacteria and poultry.Salmonella species, the gram-negative foodborne facultative anaero
Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known.Bcc bacteria are generally believed to have a predominant extra